Effectiveness and Acceptability of Progestogens in Combined Oral Contraceptives
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چکیده
Methods The objective of this review was to evaluate currently available low-dose OCs containing ethinylestradiol and different progestogens in terms of contraceptive effectiveness, cycle control, side effects and continuation rates. The Cochrane Controlled Trials Register, MEDLINE and EMBASE databases were searched. Randomized trials reporting clinical outcomes were considered for inclusion and were assessed for methodological quality and validity.
منابع مشابه
Effectiveness and acceptability of progestogens in combined oral contraceptives – a systematic review
BACKGROUND: The progestogen component of oral contraceptives (OCs) has undergone changes since it was recognized that their chemical structure can influence the spectrum of minor adverse and beneficial effects. METHODS: The objective of this review was to evaluate currently available low-dose OCs containing ethinylestradiol and different progestogens in terms of contraceptive effectiveness, cyc...
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4.1 Absorption, distribution, metabolism and excretion The disposition of various formulations of oral contraceptives used in humans differs. In general, both the oestrogenic and progestogenic compounds in combined oral contraceptives are absorbed by the gut and metabolized largely in the liver. A fraction of the absorbed dose of ethinyloestradiol and several progestogens is excreted in the bil...
متن کاملOral contraception: properties and side-effects of COCs and POPs
Combined oral contraceptives In the UK combined oral contraceptives (COCs), containing both oestrogen and progestogen, are the most popular method of contraception for women under age 30. The most common oestrogen used is ethinyl estradiol (EE), in doses between 20 and 35μg. Progestogens are classified according to their steroid structure and the timing of their introduction on to the market. T...
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Both estrogens and progestogens modify carbohydrate metabolism, and their ultimate effect depends upon the ratio of one to the other. The effect of progestogens themselves, which are responsible for increased insulin secretion and for insulin resistance, varies according to their androgenicity but increases according to the series pregnane, estrane and gonane. In contrast, estrogens impair the ...
متن کاملNewer progestogens.
OBJECTIVE To review the literature on the most recent progestogens to be developed, to provide clinical comparisons with older progestogens and to look at the potential of products not yet marketed. DATA SOURCES Searches of Medline and Popline together with requests for bibliographies from the Population Council, Wyeth-Ayerst Research and Schering Health Care. STUDY SELECTION Information fr...
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